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The issues of cardiovascular risks have been on the rise and a new study has found yet another breakthrough that could be influencing the further risks imposed on this condition. While nobody thought of the relationship between the high glucose and circadian clocks with that of obesity, this new study has something up their sleeve already.
A new study conducted by the researchers from the Medical College of Georgia at Augusta University suggest that the presence of high glucose in obesity tends to mess up with the work of the circadian clocks that further causes impacts on the body functions across the overall 24-hour day and enhance the risks of cardiovascular issues in the individuals.
Dr. David Stepp, vascular biologist in the Vascular Biology Center and Leon Henri Charbonnier Endowed Chair in Physiology at the Medical College of Georgia at Augusta University suggested that this study highlights the correlation between glucose and cardiovascular issues having direct relation with that of obesity.
In addition to that, Stepp said that they have also explained that the high glucose levels in the body do have direct impacts on the circadian clock function as well. The main objective that these researchers wanted to know whether fixing the clock would fix the risks associated with the cardiovascular risks.
The circadian rhythm of the body is a very crucial thing because of the kind of impacts it has on the overall functioning of the body, in general. While people often correlate the circadian rhythm with that of the body’s sleeping cycle, we tend to skip out on the other important factors associated.
Dr. David Fulton, director of the Vascular Biology Center and Regents professor in the MCG Department of Pharmacology and Toxicology said that every single cell present in the body does have its very own clock that helps anticipate the requirements on a daily basis.
Stepp further clarified on this, saying that the metabolic needs during the night are a lot different than what you need during the day. While some are more, there are some instances which are completely different. This suggests that nothing is static when it comes round to this.
Sleep is the time when the body gets the rest to ensure proper rejuvenation and regeneration of the cells involved in the body. This is the time when the body does all the necessary repairs required around. The blood flow in the body matches up to the requirements of the body during that specific time frame.
The circadian clock is like a mediator between the metabolism and the cardiovascular health of an individual. The researchers, from the study, have concluded that obesity has the power to break these much needed connections, causing a chaos for your body.
The consumption of excess food enriched with sugar and high carbs, which our body later breaks down into glucose, can hamper the overall circadian rhythm of the body. The researchers believe that the same is an accelerant.
For the study, the researchers documented the levels of the high glucose along with the circadian dysfunction in a mouse model. The mice used for the study had extreme levels of appetite, high glucose levels along with high blood pressure. They also had dysfunction associated with the single layer of the endothelial cells lining the blood vessels in the body.
Endothelial dysfunction has been one of the most common point of discussion associated with the cardiovascular risks. The same is also a major contributing factor when it comes round to the condition of atherosclerosis. They can cause inflammation and can enhance the oxidative stress in the body.
The researchers also bred the obese mice with restricted doses of clock reporter, which is a gear of the circadian clock that is associated with the fluorescent protein to better get an insight into the clock activity.
The clock reporter suggested huge degrades and downturns in the circadian rhythms and the associated clock related genes in the mice. The first thing that they noticed was the fact that obesity was the primary marker behind the downgrade. They second thing about the correlation of the cardiovascular health and the circadian rhythm that they wanted to look into was whether fixing one helped fix the other or not.
They wanted to check whether intermittent fasting, which has been associated with proper regulation of the glucose peaks in the blood, a marker in helping with this condition or not. Whether or not the same had impacts on the overall functioning of the metabolism, cardiovascular health and the risks is what they further wanted to look into.
The scientists realized that if the musculature is healthy in the individual despite the issue of obesity, the same can end up helping with the mitigation of the further worsening of the condition because of the high glucose levels in the body.
Stepp said that if the glucose goes into the muscle, there’s no way it can come out. It either gets used up or stored in the muscle for the upcoming needs of the body.
In addition to obesity, the researchers also point out that aging as well as spinal injuries which affect the musculature in the body could be a contributing factor behind this condition as well. Other related issues with the circadian clock could be jet lag or even insomnia, for that matter.
